MR-Guided Focused Ultrasound (MRgFUS): Incisionless Treatment

Axial T2 brain MRI (MNI ICBM152 template) labelled: skull, white matter, grey matter, lateral ventricles. Handwritten note: CSF: bright on T2.
MRI: MNI ICBM152 2009b template. Copyright (C) 1993-2004 Louis Collins, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University. Labels added.

MR-Guided Focused Ultrasound (MRgFUS): Incisionless Treatment

An incisionless treatment: MRI aims and monitors, focused ultrasound heats and destroys a tiny target deep in the body.

Updated September 2026 · 1 source listed

On this pageHow it worksEstablished usesPractical notesSources

How it works

Hundreds of ultrasound beams are focused to converge on a single point, raising its temperature enough to ablate tissue while sparing everything the beams pass through. MRI provides the targeting and real-time MR thermometry, measuring temperature during treatment so the operator sees the ablation forming and keeps it controlled. No incision, no radiation.

MR thermometry makes this a monitored, closed-loop ablation.

Established uses

  • Essential tremor & tremor-dominant Parkinson’s: thalamotomy of the Vim nucleus, often with immediate reduction in hand tremor. It is an alternative to deep brain stimulation for selected patients.
  • Uterine fibroids: non-invasive ablation as an alternative to surgery/embolisation in suitable cases.
  • Painful bone metastases: palliation of pain when other options are limited.

Research is active in prostate, breast and neurological applications.

Practical notes

Suitability depends on target location and the acoustic window (e.g. skull density ratio for brain treatment; fibroid position and bowel in the beam path for uterine).

Sources

  1. Elias WJ et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2016;375:730–39.

Educational summary; availability and eligibility vary by centre and indication. Not medical advice.

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